IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering
S. Karnewar, V. KARNEWAR, R. A. Deaton, L. S. Shankman, E. Benavente, C. Williams, X. Bradley, G. F. Alencar, G. Bulut, S. Kirmani, R. Baylis, E. Zunder, H. H. den Ruijter, G. Pasterkamp, G. K. Owens
This study shows that inhibiting IL-1β in mice reduces the beneficial effects of diet-induced lipid lowering on atherosclerosis, increasing plaque burden and decreasing plaque stability.
bioRxiv · Oct 13, 2023 · PreprintCell Biology