Author

E.-M. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:E. coli· 1 Assay:metagenomics· 1

Frequent Co-Authors

C.-F. Wu· 2 shared L.-K. Sung· 2 shared M. N. M. Santos· 2 shared M. Yu· 2 shared Y.-L. Shih· 2 shared A.-P. Chen· 1 shared C. H. Kuo· 1 shared C.-H. Kuo· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

C.-F. Wu

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Agrobacteria deploy two classes of His-Me finger superfamily nuclease effectors exerting different antibacterial capacities against specific bacterial competitors

M. N. M. Santos, K. L. Pintor, P.-Y. Hsieh, Y.-W. Cheung, L.-K. Sung, Y.-L. Shih, E.-M. Lai

This study identifies two His-Me finger nucleases, V2a and V2c, from Agrobacterium tumefaciens, showing they have distinct antibacterial activities against different bacterial competitors.

bioRxiv · Mar 20, 2023Microbiology

Development of a soil inoculation method coupled with blocker-mediated 16S rRNA gene amplicon sequencing reveals the effect of antibacterial T6SS on agrobacteria tumorigenesis and gallobiome composition

S.-C. Wang, A.-P. Chen, S.-J. Chou, C. H. Kuo, E.-M. Lai

This study develops a soil inoculation method with blocker-mediated 16S rRNA gene sequencing to show that the T6SS in Agrobacteria promotes tumorigenesis and affects gallobiome composition through interbacterial competition.

bioRxiv · Oct 28, 2022Microbiology

A glycine zipper motif governs translocation of type VI secretion toxic effectors across the cytoplasmic membrane of target cells

J. Ali, M. Yu, L.-K. Sung, Y. W. Cheung, E.-M. Lai

The paper identifies a glycine zipper motif in Tde1 that enables membrane permeabilization and translocation into target cells.

bioRxiv · Jul 12, 2022 · PreprintMicrobiology

Redundancy and specificity of type VI secretion vgrG loci in antibacterial activity of Agrobacterium tumefaciens 1D1609 strain

M. N. M. Santos, S.-T. Cho, C.-F. Wu, C.-J. Chang, C.-H. Kuo, E.-M. Lai

This study investigates the redundancy and specificity of multiple vgrG genes in Agrobacterium tumefaciens 1D1609, showing functional redundancy in T6SS secretion and antibacterial activity.

bioRxiv · Aug 19, 2019Microbiology

Identification of Escherichia coli ClpAP in regulating susceptibility to type VI secretion system-mediated attack by Agrobacterium tumefaciens

H.-H. Lin, M. Yu, M. K. Sriramoju, S.-T. D. Hsu, C.-T. Liu, E.-M. Lai

The paper identifies ClpAP in E. coli as a factor influencing susceptibility to T6SS-mediated killing by A. tumefaciens.

bioRxiv · Aug 14, 2019Microbiology

Effector loading onto VgrG spike proteins is critical for the assembly of the type VI secretion system in Agrobacterium tumefaciens

Y.-W. Lien, C.-F. Wu, D. Bondage, J.-S. Lin, Y.-L. Shih, J. Chang, E.-M. Lai

This study shows that loading effectors onto VgrG spike proteins is essential for T6SS assembly and function in Agrobacterium tumefaciens.

bioRxiv · Feb 21, 2019 · PreprintMicrobiology