M. Yu

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

Human ANP32A/B are SUMOylated and utilized by avian influenza virus NS2 protein to overcome species-specific restriction

This study shows that human ANP32A/B are SUMOylated, enabling avian influenza virus NS2 to enhance polymerase activity and overcome species-specific restrictions.

Deep learning of protein energy landscape and conformational dynamics from experimental structures in PDB

This study develops DeepConformer, a diffusion model that learns protein conformational dynamics and energy landscapes from PDB structures and coevolution data, reproducing MD simulation results without using MD data.

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

DNA-based ForceChrono Probes for Deciphering Single-Molecule Force Dynamics in Living Cells

This paper introduces DNA-based ForceChrono probes to measure single-molecule force dynamics in living cells, revealing precise loading rates and a link between force magnitude and duration.

Protein-specific crowding accelerates aging in phase-separated droplets

This study shows that PEG affects phase-separated droplets differently depending on the protein, accelerating Nup98 maturation but stabilizing BSA droplets.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

LrhA promotes CRISPR-Cas immunity by enhancing primed adaptation in Escherichia coli

This study identifies LrhA as a regulator that enhances CRISPR-Cas immunity in E. coli by promoting adaptation through increased spacer acquisition.

The SUMO-interacting Motif in NS2 promotes adaptation of avian influenza virus to mammals

This study identifies NS2's SUMO-interacting motif as critical for avian influenza virus adaptation to mammals by enhancing vRNP assembly and ANP32A/B interactions.

Single-cell transcriptomic analysis of pea shoot development and cell-type-specific responses to boron deficiency

This study uses single-cell RNA sequencing to analyze pea shoot development and cell-type-specific responses to boron deficiency, revealing differential gene expression and developmental impacts.

Toleration of Frameshift Mutations in mRNA Sequences Encoding the N-terminal Peptides of Bacterial Type III Effectors

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

Redundant and distinct roles of two 14-3-3 proteins in Fusarium sacchari, pathogen of sugarcane Pokkah boeng disease

This study investigates the roles of two 14-3-3 proteins in Fusarium sacchari, showing redundancy and distinct functions in pathogenicity and development.

Genetic control of cell layer interactions in plants via tissue mechanics

The paper shows that brassinosteroid genes control tissue growth coordination in plants by modulating mechanical constraints between cell layers.

Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm

This paper develops a multi-model platform to study atrial fibrillation-associated genes, identifying phospholamban as a key regulator of cardiac rhythm through interactions with calcium handling proteins.

Genomic and transcriptional profiling stratifies VQ myeloma lines into two clusters with distinct risk signatures and drug responses

Prevalent regulation of GATA2/3 and MSX2 on endogenous retrovirus-derived regulatory elements in human trophoblast stem cells

This study identifies GATA2/3 and MSX2 as key regulators of ERV-derived enhancers in human trophoblast stem cells, revealing their role in placental gene regulation.

A glycine zipper motif governs translocation of type VI secretion toxic effectors across the cytoplasmic membrane of target cells

The paper identifies a glycine zipper motif in Tde1 that enables membrane permeabilization and translocation into target cells.

Deciphering the conformations and dynamics of FG-nucleoporins in situ

This study uses fluorescence microscopy and modeling to reveal the conformation and dynamics of FG-NUPs within the nuclear pore complex, showing good-solvent conditions facilitate transport.

Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis

The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

Boron Supply Restores Aluminum-Blocked Auxin Transport by Modulation PIN2 Trafficking in the Arabidopsis Roots

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myeloma

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

CAR modulates plasma membrane nano-organization and immune signaling downstream of RALF1-FERONIA signaling pathway

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

Mechano-Biochemical Regulation of the C. elegans HMP1-HMP2 protein complex

This study investigates how mechanical tension regulates the stability and function of the HMP1-HMP2 protein complex in C. elegans, revealing its role in mechanotransduction.

Comparative untargeted metabolomic profiling of induced mitochondrial fusion in pancreatic cancer

The paper compares metabolic changes induced by three methods of mitochondrial fusion in pancreatic cancer cells and identifies common amino acid metabolism alterations.

Botrytis cinerea BcPTP1 is a late infection phase, cysteine rich protein cytotoxic effector

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

Loss of MGA mediated Polycomb repression promotes tumor progression and invasiveness

This study shows that loss of MGA promotes tumor growth and invasiveness by de-repressing Polycomb targets in lung and colon cancers.

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.