Stabilizing membrane domains antagonizes n-alcohol anesthesia
B.B. Machta, E. Grey, M. Nouri, N.L.C. McCarthy, E.M. Gray, A.L. Miller, N.J. Brooks, S.L. Veatch
This study shows that changes in membrane phase separation temperature (Tc) better predict n-alcohol anesthetic potency than hydrophobicity, supporting a role for membrane heterogeneity in anesthesia.
bioRxiv · Jun 7, 2016 · PreprintBiophysics