Precision Targeting of Troponin I Phosphorylation Prevents Diastolic Dysfunction while Preserving Systolic Performance
Ying‐Chi Chao, Debra J. McAndrew, David Revuelta, Rahul Yadav, Wan-Hua Hong, Jianshu Hu, Milda Folkmanaite, Edoardo Valli, Mariana Gee Olmedilla, Andreas Koschinski, Nicoletta Concetta Surdo, Jakub Tomek, Diederik W.D. Kuster, Helen V. Edwards, Connor M. Blair, , Manuela Zaccolo
This paper identifies a nanodomain mechanism regulating troponin I phosphorylation and demonstrates a peptide that selectively enhances relaxation without compromising systolic function in heart failure.
bioRxiv · Nov 18, 2025 · PreprintCell Biology