Generative 3D Spatial Reconstruction of Cellular Organization from Single Cell Expression
Ehtesamul Azim, Muhtasim Noor Alif, Tae Hyun Hwang, Hao Zheng, Wei in Zhang
ORBIS reconstructs 3D tissue geometry from single-cell gene expression without spatial references, achieving lower shape error and faster sampling than existing methods.
bioRxiv · Nov 6, 2026 · PreprintBioinformatics