Intracellular TDP-43 amyloid nucleates from arrested nascent condensates
Jianzheng Wu, Shriram Venkatesan, Jacob Jensen, Tayla Miller, Jeffrey J. Lange, Sean McKinney, Einar Halldorsson, Zulin Yu, Vignesh M. P. Babu, Laura Sancho Salazar, Jeff Haug, Jay R. Unruh, Randal Halfmann
This study shows TDP-43 amyloid forms only when its C-terminal domain arrests in soluble clusters, and this process can be inhibited by co-expressing an oligomeric binder.
bioRxiv · Mar 9, 2026 · PreprintBiophysics