Jacob Jensen

Nascent protein retention at polysomes reduces kinetic barriers to self-assembly

The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.

Intracellular TDP-43 amyloid nucleates from arrested nascent condensates

This study shows TDP-43 amyloid forms only when its C-terminal domain arrests in soluble clusters, and this process can be inhibited by co-expressing an oligomeric binder.

A tool to dissect heterotypic determinants of homotypic protein phase behavior

The paper introduces a tool to study how modifier proteins affect the phase behavior of query proteins through controlled interaction modulation.

A tunable affinity fusion tag for protein self-assembly

This paper introduces a tunable amyloid-based fusion tag that allows precise control of protein concentration thresholds in cells.