Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 Function
Claire D. James, Aya H. Youssef, Apurva Tadimari Prabhakar, Jenny D Roe, Elinor Lu, Austin Witt, Sarita Giri, Molly L. Bristol, Phoebe V. Bridy, Xu Wang, Arjun Rijal, Charles E. Lyons, Iain M. Morgan
This study identifies novel host factors interacting with HPV16 E2 during differentiation using proximity proteomics, revealing a cooperative E2-TOPBP1-NCL axis critical for viral genome stability.
mBio · Jan 12, 2026Peer-reviewedCancer Biology