Aya H. Youssef

This paper shows that HPV16 requires SMARCAL1 to recruit to viral and host replication forks, which is essential for its life cycle and prevents DNA damage and genome integration.

This study identifies novel host factors interacting with HPV16 E2 during differentiation using proximity proteomics, revealing a cooperative E2-TOPBP1-NCL axis critical for viral genome stability.

This paper develops a fibroblast co-culture model to predict drug responses in HPV+ cancers and shows it better predicts in vivo outcomes than in vitro alone.

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

This paper identifies a mitotic E2-TopBP1 complex that inactivates SIRT1, promoting E2 acetylation and stability through p300, which protects against ubiquitination and proteasomal degradation.