Author

Eliot Mar

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Dieter BrömmeiD· 4 shared S. Yasin Tabatabaei DakhiliiD· 4 shared Olivier HinseiD· 3 shared Dipon SahaiD· 2 shared Filip Van PetegemiD· 2 shared Jason C. RogalskiiD· 2 shared Leonard J. FosteriD· 2 shared Preety PanwariD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiochemistry

Dieter BrömmeORCID

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Author profile →

4 papers

Recent·Most cited

Cathepsin K Mediates the Formation of Potential Rheumatoid Arthritis-Relevant Cis- and Trans-Spliced Peptides Compatible With HLA-DR4 Presentation

Olivier Hinse, S. Yasin Tabatabaei Dakhili, Lee Freiburger, Eliot Mar, Jason C. Rogalski, Sriram Subramaniam, Eddie A. James, Leonard J. Foster, Dieter Brömme

This study identifies cathepsin K-generated spliced peptides as potential autoantigens in RA, compatible with HLA-DR4 presentation.

bioRxiv · Sep 10, 2026 · PreprintBiochemistry

Functional Characterization of SARS-CoV-2 3CLpro Variants

Dipon Saha, S. Yasin Tabatabaei Dakhili, Eliot Mar, Yu Seby Chen, Filip Van Petegem, Dieter Brömme

This study examines how SARS-CoV-2 3CLpro variants maintain catalytic activity despite distant substitutions, revealing structural adaptations that preserve function.

bioRxiv · Sep 10, 2026 · PreprintBiochemistry

Cathepsin K as a Key Protease in Processing of SARS-CoV-2 Spike Activation Sites and a Target of Dual-Inhibition

S. Yasin Tabatabaei Dakhili, Dipon Saha, Preety Panwar, Eliot Mar, Olivier Hinse, Yu Seby Chen, Bryan J. Fraser, C.H. Arrowsmith, Masahiro Niikura, Filip Van Petegem, Dieter Brömme

This study identifies Cathepsin K as a key host protease for SARS-CoV-2 spike activation and shows it can be inhibited by existing drugs.

bioRxiv · Oct 3, 2025 · PreprintBiochemistry

Reverse Proteolysis Uncovers a Hidden Dimension of the Peptidome

S. Yasin Tabatabaei Dakhili, Preety Panwar, Olivier Hinse, Eliot Mar, Jason C. Rogalski, Leonard J. Foster, Dieter Brömme

This paper demonstrates that lysosomal cysteine cathepsins can generate fusion peptides through reverse proteolysis, revealing a new dimension of protease activity and peptide diversification.

bioRxiv · Sep 2, 2025 · PreprintBiochemistry