Author
University of British ColumbiaORCID 0000-0002-0793-2391Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Dipon Saha, S. Yasin Tabatabaei Dakhili, Eliot Mar…·Dieter Brömme
This study examines how SARS-CoV-2 3CLpro variants maintain catalytic activity despite distant substitutions, revealing structural adaptations that preserve function.
S. Yasin Tabatabaei Dakhili, Dipon Saha, Preety Panwar…·Dieter Brömme
This study identifies Cathepsin K as a key host protease for SARS-CoV-2 spike activation and shows it can be inhibited by existing drugs.
Olivia Pfeil-Gardiner, Higor Vinícius Dias Rosa, Dietmar Riedel…·Bonnie J. Murphy
This paper introduces REEL-EM, a method combining EELS and single-particle image processing to enable elemental mapping in cryo-preserved macromolecular complexes, demonstrating reliable localization of abundant elements.
Thomas T. Joseph, Weiming Bu, Omid Haji‐Ghassemi…·Roderic G. Eckenhoff
This study shows propofol directly binds and inhibits RyR1, reducing Ca2+ release and potentially protecting against malignant hyperthermia.