Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates
Wade W. Sugden, Stephan George, Zachary C. LeBlanc, Morgan T. Walcheck, Eleanor Meader, Julia Goldstein, Elizabeth Molnar, Wandi Zhu, Rubul Mout, Christopher Li, Leah Radeke, Zoey Young, Maria Gonzalez di Tillio, Marcelo Falchetti, Mohamad Ali Toufic Najia, , Trista E. North
This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.
bioRxiv · Jun 23, 2026 · PreprintCell Biology