Cell BiologybioRxivPreprint
Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates
Wade W. Sugden, Stephan George, Zachary C. LeBlanc…·Trista E. North
This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.