Sex Differences in the Effects of Controlled Circadian Dysregulation on Gut Microbiome and Intestinal Barrier Architecture
Ella Barnum, Jonathan Louis Turck, Karienn A. de Souza, Kathiresh Kumar Mani, Rachel Pilla, Amutha Selvamani, Farida Sohrabji, David J. Earnest
This study shows that circadian dysregulation caused by shifted light-dark cycles worsens gut microbiome and intestinal barrier issues more in male than female rats, contributing to sex differences in stroke outcomes.
bioRxiv · Jan 26, 2026 · PreprintPhysiology