Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain
Alicia Bedolla, Elliot Wegman, Max Weed, Messiyah K. Stevens, Kierra Ware, Aditi Paranjpe, Anastasia Alkhimovitch, Igal Ifergan, Александр Таранов, Joshua D. Peter, Rosa Maria Salazar Gonzalez, J. Elliott Robinson, Lucas McClain, Krishna M. Roskin, Nigel H. Greig, Yu Luo
This study identifies microglia as the primary source of TGF-β1 ligand in the adult mouse brain, showing its role in maintaining microglial homeostasis and cognitive function through an autocrine mechanism.
Nature Communications · Jun 21, 2024Peer-reviewedNeuroscience