Author

Emanuela Elezi

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Kevin CorreiaiD· 3 shared Ricardo Mouro PintoiD· 3 shared Tammy GillisiD· 3 shared Vanessa Chantal WheeleriD· 3 shared Esaria OliveriD· 2 shared James F. GusellaiD· 2 shared Marcy E. MacDonald· 2 shared Marina V. KovalenkoiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersGenetics

Kevin CorreiaORCID

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3 papers

Recent·Most cited

Somatic CRISPR editing of Msh3 mitigates Huntington's disease pathology in mice

Esaria Oliver, Marina V. Kovalenko, Mathilde Louçã, Andrew Jiang, Jordan Westerdahl, Kevin Correia, Ben P Jones, Faaiza Saif, Nicole Romano, Ashna Sidhu, Tammy Gillis, Emanuela Elezi, Ryan Murtha, Ricardo Mouro Pinto, Vanessa Chantal Wheeler

This study shows that knocking out Msh3 in mice with Huntington's disease slows CAG expansion and reduces pathology, with earlier intervention being more effective.

bioRxiv · Jun 10, 2026 · PreprintGenetics

Identification of genetic modifiers of Huntington's disease somatic CAG repeat instability by in vivo CRISPR-Cas9 genome editing

Ricardo Mouro Pinto, Ryan Murtha, António Azevedo, Cameron J. Douglas, Marina V. Kovalenko, Jessica Ulloa, Steven Crescenti, Zoe N. Burch, Esaria Oliver, Maheswaran Kesavan, Shota Shibata, Antonia G. Vitalo, Eduarda Mota‐Silva, Marion J. Riggs, Kevin Correia, , Vanessa Chantal Wheeler

The paper identifies genetic modifiers of Huntington's disease somatic CAG repeat instability using CRISPR-Cas9 in HD knock-in mice, revealing new therapeutic targets.

Nature Genetics · Jan 22, 2025Peer-reviewedGenetics

Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease reveal shared and tissue-specific effects

Jong‐Min Lee, Zachariah L. McLean, Kevin Correia, Jun Wan Shin, Sujin Lee, Jae-Hyun Jang, Yukyeong Lee, Kyung‐Hee Kim, Doo Eun Choi, Jeffrey D. Long, Diane E. Lucente, Ihn Sik Seong, Ricardo Mouro Pinto, James V. Giordano, Jayalakshmi Srinidhi Mysore, , Richard H. Myers

The paper identifies genetic modifiers of somatic CAG expansion and clinical phenotypes in Huntington's disease, revealing shared and tissue-specific effects on disease timing and pathogenic processes.

bioRxiv · Jun 10, 2024 · PreprintGenetics