Author

Faaiza Saif

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew JiangiD· 2 shared Esaria OliveriD· 2 shared Marina V. KovalenkoiD· 2 shared Ricardo Mouro PintoiD· 2 shared Ryan MurthaiD· 2 shared Tammy GillisiD· 2 shared Vanessa Chantal WheeleriD· 2 shared Ashna Sidhu· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenetics

Andrew JiangORCID

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Author profile →

3 papers

Recent·Most cited

Hypoxia induces cytotoxicity and suppresses cytokine production by CD8⁺ T cells in cutaneous leishmaniasis.

Erin A. Fowler, Olivia L. Schneider, Faaiza Saif, Fernanda O. Novais

This study shows hypoxia in leishmaniasis lesions reprograms CD8⁺ T cells to become cytotoxic while suppressing protective cytokine production.

bioRxiv · Aug 4, 2026 · PreprintImmunology

Somatic CRISPR editing of Msh3 mitigates Huntington's disease pathology in mice

Esaria Oliver, Marina V. Kovalenko, Mathilde Louçã, Andrew Jiang, Jordan Westerdahl, Kevin Correia, Ben P Jones, Faaiza Saif, Nicole Romano, Ashna Sidhu, Tammy Gillis, Emanuela Elezi, Ryan Murtha, Ricardo Mouro Pinto, Vanessa Chantal Wheeler

This study shows that knocking out Msh3 in mice with Huntington's disease slows CAG expansion and reduces pathology, with earlier intervention being more effective.

bioRxiv · Jun 10, 2026 · PreprintGenetics

Huntington's disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansion

Eunhye Lee, Wonju Kim, David H. Beier, Yejin Lee, Marina V. Kovalenko, Faaiza Saif, Esaria Oliver, Bhairavi Srinageshwar, Ryan Murtha, Marissa A Andrew, Andrew Jiang, Tammy Gillis, Brigitte Demelo, Jayla Ruliera, Diane E. Lucente, , Ihn Sik Seong

This paper investigates the protective effect of the LIG1 K845N variant in Huntington's disease by showing it increases ligase fidelity and suppresses somatic CAG repeat expansion.

Proceedings of the National Academy of Sciences · Mar 2, 2026Peer-reviewedGenetics