Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression
Amin Abedini, Jonathan L. Levinsohn, Konstantin A. Klötzer, Bernhard Dumoulin, Ziyuan Ma, Julia Frederick, Poonam Dhillon, Michael S. Balzer, Rojesh Shrestha, Hongbo Liu, Steven Vitale, Kishor B. Devalaraja-Narashimha, Paola Grandi, Tanmoy Bhattacharyya, Erding Hu, , Katalin Suszták
Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.
bioRxiv · Oct 24, 2022 · PreprintGenetics