Christopher A. Hunter

This study compares CD8+ T cell and antibody responses in non-human primates using different ratios of modified and unmodified mRNA-LNP vaccines with IL-12 boosting.

This study evaluates an H5 mRNA-LNP vaccine in lactating dairy cows, finding it reduces viral replication and disease in mammary glands.

This study identifies a complex male fertilization apparatus in Cryptosporidium, essential for infection, and shows that disrupting HAP2 prevents fertilization and clears infection.

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

This study investigates gestational stage-dependent differences in maternal and fetal outcomes following Oropouche virus infection in mice, revealing fetal-intrinsic antiviral mechanisms.

This study identifies altered purinergic signaling and CD8+ T cell dysregulation in STAT3 GOF syndrome, showing partial normalization with JAK inhibitors.

This study investigates the role of integrins in T cell trafficking and resistance to Cryptosporidium parvum, finding that integrin L is critical for T cell-mediated control of infection while 4β7 is not essential.

This study shows that misoprostol reduces C. difficile infection severity by decreasing neutrophil infiltration and G-CSF levels, highlighting innate immune modulation as a therapeutic strategy.

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

The paper develops the STORE.2 model to simulate CD8+ T cell proliferation and response to antigen presentation, showing its accuracy in vitro and in vivo.

The paper compares neuronal transcriptional responses to Toxoplasma gondii and RNA viruses, identifying conserved and pathogen-specific immune responses in neurons.

This study identifies IL-27 as an antiviral cytokine at the maternal-fetal interface, showing it restricts Zika virus infection in placental trophoblast organoids and mouse models.

This study shows immune pressure targets Toxoplasma gondii bradyzoites, which mitigate tissue damage and promote host-parasite survival.

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.

This study uses single-cell RNA sequencing to analyze how intestinal epithelial cells respond to Cryptosporidium infection and IFN-gamma, showing delayed parasite reduction with cytokine treatment.

The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.

The paper shows that dendritic cells are essential for CD8+ T cell responses to Cryptosporidium effectors, which are secreted by the parasite.

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.