Rojesh Shrestha

The paper introduces ExIGS, a method linking nuclear abnormalities to chromatin repression hotspots in progeria fibroblasts.

The paper shows that the epigenetic state of the cell of origin influences susceptibility to Tet2 mutation, with Sox4 promoting dedifferentiation and increased clonal output in hematopoietic stem cells.

The paper introduces PRINT, a deep learning method to correct chromatin accessibility data and analyze DNA-protein interactions, revealing structural and functional changes in cis-regulatory elements during hematopoiesis and aging.

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.

The paper maps the regulatory landscape of the mouse kidney at single cell resolution, identifying key transcription factors and regulatory circuits, and linking variants to kidney disease.

This study identifies the cellular origins of perivascular adipose tissue using single-cell transcriptomics, fate mapping, and adipogenesis assays, revealing fibroblastic and smooth muscle progenitors.

This study shows that Dnmt1 is critical for kidney development by maintaining methylation of transposable elements in Six2 progenitor cells, preventing their regression and ERV activation.