Author

Eric Weh

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Heather M. Hager· 4 shared Thomas J. WubbeniD· 4 shared Cagri G. BesirliiD· 3 shared Costas Andreas LyssiotisiD· 3 shared Peter SajjakulnukitiD· 3 shared Andrew J. H. SmithiD· 2 shared Katherine M. WehiD· 2 shared Mercy D. Pawar· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersNeuroscience

Heather M. Hager

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Author profile →

5 papers

Recent·Most cited

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress

Meini Chen, Eric Weh, Moloy T. Goswami, Katherine M. Weh, Heather M. Hager, Peter Sajjakulnukit, Avi Weingarten, Shubha Subramanya, Nicholas Miller, Sraboni Chaudhury, Emma Piraino, Navdeep S. Chandel, Renee C. Ryals, Costas Andreas Lyssiotis, Thomas J. Wubben

This study shows that GOT1 and GOT2 have opposing roles in rod photoreceptor health, with GOT2 acting as a neuroprotective factor under reductive stress conditions.

Redox Biology · Jun 18, 2026Peer-reviewedNeuroscience

Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

Moloy T. Goswami, Eric Weh, Shubha Subramanya, Katherine M. Weh, Hima Bindu Durumutla, Heather M. Hager, Nicholas Miller, Sraboni Chaudhury, Anthony C. Andren, Peter Sajjakulnukit, Li Zhang, Cagri G. Besirli, Costas Andreas Lyssiotis, Thomas J. Wubben

eLife · Aug 28, 2024Peer-reviewedCell Biology

Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress

Eric Weh, Zuzanna Lutrzykowska, Andrew J. H. Smith, Heather M. Hager, Mercy D. Pawar, Thomas J. Wubben, Cagri G. Besirli

This study shows that HK2 is not needed for photoreceptor development but is essential for their survival during aging and stress, with its non-enzymatic role in AKT signaling being critical.

Cell Death and Disease · Jun 4, 2020Peer-reviewedNeuroscience

Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, provides photoreceptor neuroprotection

Thomas J. Wubben, Mercy D. Pawar, Eric Weh, Andrew J. H. Smith, Peter Sajjakulnukit, Li Zhang, Lipeng Dai, Heather M. Hager, Manjunath P. Pai, Costas Andreas Lyssiotis, Cagri G. Besirli

This study shows that activating PKM2 with ML-265 protects photoreceptors from stress-induced apoptosis in vitro and in vivo.

Scientific Reports · Feb 19, 2020Peer-reviewedMolecular Biology

Deletions of distant regulatory sequences upstream of zebrafish pitx2 result in a range of ocular phenotypes.

Eric Weh, Elena Sorokina, Kathryn Hendee, Doug B. Gould, Elena V. Semina

The paper studies deletions in the upstream regulatory region of zebrafish pitx2 and their effects on ocular development and DNA methylation.

bioRxiv · Sep 18, 2019 · PreprintGenetics