Li Zhang

Receptor-like kinase RLK15 binds a fungal RNase effector to enhance autophosphorylation and activate host defense

The paper identifies a fungal RNase effector recognized by a plant receptor kinase, triggering immune responses and enhancing disease resistance.

Proximity-mapped whole-genome sequencing for characterization of repeat expansions and variants in highly homologous genomic regions

This study evaluates TruPath Genome's ability to characterize repeat expansions and variants in complex genomic regions using archived DNA samples, showing consistent results with orthogonal methods.

AnnoAudit: a marker-based protocol for auditing single-cell atlas annotations reveals systematic, state-dependent annotation failure in a widely used traumatic brain injury resource

A marker audit finds 97.9% of CEREBRI's 45,051 official 'glutamatergic neuron' cells are not glutamatergic (four-check composite 82.6%), creating false ion-channel and OXPHOS signals; true neurons show acute KCNC3 up-regulation.

Conserved microglial programmes, non-transferable classifiers: boundaries of the single-cell TBI molecular clock

This paper evaluates the transferability of a single-cell molecular clock for traumatic brain injury (TBI) staging across datasets, finding poor cross-dataset generalization and identifying a conserved microglial gene-expression programme as the reproducible component.

Genetic background diversifies mutational paths but converges on membrane depolarization for bleomycin resistance in yeast

This study shows that while genetic background shapes mutational paths to bleomycin resistance in yeast, all backgrounds converge on membrane depolarization via PMA1 and PTK2 mutations.

Shared binding sites for the chromosomal architectural protein Su(Hw) mediate physical interactions between Drosophila TAD boundaries

The paper investigates how shared Su(Hw) binding sites between TAD boundaries affect long-distance regulation and physical interactions in Drosophila.

Programming Biomolecular Interactions with All-Atom Generative Model

This paper introduces AnewOmni, a generative model that designs biomolecules across scales by learning interaction patterns and physical constraints from 5 million complexes.

Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer

This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.

Transcranial direct current stimulation combined cognitive training modulates risk-taking behavior in older adults

This study shows that combining tDCS with cognitive training improves risk-taking behavior in older adults by altering brain network connectivity and decision-making processes.

Macrophage Iron Metabolism in Allografts and Tumors

This study identifies SLC11A1 as a key regulator of macrophage iron metabolism in allografts and tumors, showing its role in inflammation and rejection.

The Promotive Effect of Ocean Literacy on Marine Conservation Behavior: A Qualitative Study Based on Chinese University Students

This study investigates how ocean literacy influences marine conservation behaviors among Chinese university students through qualitative interviews and thematic analysis.

Versatile Stain Transfer in Histopathology Using a Unified Diffusion Framework

This paper introduces DUST, a diffusion model for histopathology stain transfer, showing improved performance over GAN-based methods on a kidney histopathological dataset.

Cerebellin-2 neurons in the parafascicular thalamic nucleus regulate self-grooming behavior

This study identifies Cbln2+ neurons in the parafascicular thalamic nucleus as regulators of self-grooming behavior, showing bidirectional control and potential for non-invasive OCD treatment.

A Comprehensive Assessment of Methylation-Based Age Prediction Methods

This study benchmarks 15 DNA methylation age prediction methods across 142 datasets, finding that model performance depends on training data characteristics and providing a resource for future research.

A signal of temporal integration in the human auditory brain: psychological insights, EEG evidence, and clinical application

This study investigates temporal integration in the human auditory system using EEG and finds that regular transitional click trains elicit distinct neural responses compared to irregular ones, with clinical implications for coma diagnosis.

Genomic and transcriptomic profiles influence on brain morphology and their interactions with pain sensitivity individual differences

This study investigates how genomic and transcriptomic profiles interact with brain morphology to influence individual differences in pain sensitivity using multi-omics data from 432 participants.

Engulfment of viable neurons by reactive microglia in prion diseases

The paper shows that in prion diseases, microglia engulf viable neurons during late preclinical stages, independent of the CD11b pathway, and this occurs across multiple brain regions and sCJD subtypes.

A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16

This paper develops and evaluates [18F]SDM-16, a metabolically stable SV2A PET tracer, showing high affinity and specific binding in nonhuman primate brains.

Atypically larger variability of resource allocation accounts for visual working memory deficits in schizophrenia

This study shows that schizophrenia patients have larger variability in memory resource allocation, not reduced capacity, explaining their visual working memory deficits.

Leveraging the Mendelian Disorders of the Epigenetic Machinery to Systematically Map Functional Epigenetic Variation

The paper identifies shared epigenetic and transcriptomic disruptions across three MDEMs to map functional epigenetic variation.

Bmmp influences wing shape by regulating anterior-posterior and proximal-distal axis development

This study identifies Bmmp as a gene regulating wing shape in silkworms and Drosophila by modulating axis development, revealing its functional conservation and potential for pest control.

Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome

The paper shows that inhibiting KDM1A activity rescues adult neurogenesis and hippocampal memory defects in a mouse model of Kabuki syndrome.

CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators

CIGAR-seq identifies mRNA modification regulators through CRISPR screening and RNA modification readout, revealing NSUN6 as a novel m5C methyltransferase.

Transferrin plays a central role to maintain coagulation balance by interacting with clotting factors

This study identifies transferrin as a clotting factor that modulates coagulation balance by interacting with clotting factors and antithrombin III, with implications for atherosclerosis.

Unexpected higher resilience to distraction during visual working memory in schizophrenia

This study examines visual working memory and distractibility in schizophrenia, finding that patients show unexpected higher resilience to distraction but worse overall performance.

Long-range infra-sound acoustic signaling inhuman in vivo

The paper investigates long-range infrasound transmission in acupuncture, finding significant unidirectional transmission at 50-80cm but not in reverse directions.