Author

Erick Astacio

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:Drosophila· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Amita SehgaliD· 2 shared Caitlin E. RandolphiD· 1 shared Connor H. Beveridge· 1 shared Elana S. PyfromiD· 1 shared Erik Nash· 1 shared Gaurav ChopraiD· 1 shared Gregory R. GrantiD· 1 shared Houssein Fazelinia· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

Amita SehgalORCID

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2 papers

Recent·Most cited

Gut-derived serine protease reduces sleep but extends lifespan

Rebecca S. Moore, Richard Xiong, Erick Astacio, Julie A. Williams, Thomas G. Brooks, Gregory R. Grant, Joseph A. Stucynski, Houssein Fazelinia, Erik Nash, Lynn A. Spruce, Amita Sehgal

This study identifies a gut-derived serine protease that reduces sleep but extends lifespan in Drosophila by increasing peripheral ROS, suggesting a link between sleep reduction and stress adaptation.

bioRxiv · Jun 29, 2026 · PreprintGenetics

Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism

Elana S. Pyfrom, Connor H. Beveridge, Paula R. Haynes, Vishal A. Kanigicherla, Caitlin E. Randolph, Paula Carvalho Costa, Seble G. Negatu, Sanjay N. Iyer, Samantha L. Killiany, Zhifeng Yue, Erick Astacio, Katherine A. Walker, Kiet N. Luu, Pavel Pivarshev, Kellie A. Jurado, , Amita Sehgal

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

bioRxiv · Sep 10, 2025 · PreprintNeuroscience