Amita Sehgal

This study combines respirometry and metabolomics to analyze circadian metabolic dynamics in Drosophila, showing how sleep and circadian disruptions affect metabolic rates and redox homeostasis.

This study shows that acute ethanol inverts the relationship between sleep and memory in Drosophila, causing sleep to hinder memory consolidation.

This study identifies glia as key coordinators of sickness-induced sleep behavior through an adrenergic-glutamatergic axis in Drosophila.

This study identifies a gut-derived serine protease that reduces sleep but extends lifespan in Drosophila by increasing peripheral ROS, suggesting a link between sleep reduction and stress adaptation.

This study shows that sleep enhances endocytosis in brain endothelial cells, aiding waste removal, and that blocking endocytosis increases sleep need.

The paper shows that sleep in Drosophila allows peripheral hemocytes to clear lipids from the brain, and this process is mediated by the eater receptor.

The paper identifies regulators of dopamine and sleep in Drosophila by screening genes affecting cuticle pigmentation, finding novel genes like mask that influence dopamine metabolism and behavior.

This study shows that sleep regulates peroxisomal abundance to reduce brain oxidation caused by wakefulness, with Pex16 playing a key role in sleep regulation and lipid metabolism.

The paper shows that disrupting light cycles during a critical window reduces time-of-day protection from influenza, but rhythmic meal timing can compensate, highlighting the role of environmental cues in immune response.

The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.

This study shows that constant light impairs associative memory in Drosophila for three generations, mediated by the PIWI/piRNA pathway and Dopamine-1-like Receptor 1.

This study shows that tanycyte Bmal1 deletion in female mice reduces weight gain on high-fat diet by altering hypothalamic neurogenesis, specifically affecting feeding-suppressing POMC neurons.

The paper identifies RNA processing genes modulated during sleep-dependent memory in Drosophila and shows their effects on sleep and memory consolidation.

This study shows that age-related blood-borne factors alter circadian gene expression in cultured fibroblasts, affecting oxidative phosphorylation and cholesterol biosynthesis pathways.

This study shows that Nf1 loss in Drosophila causes sleep disturbances via starvation due to metabolic defects linked to SARM1-dependent NAD+ metabolism.

This study shows that metabolic activity in cancer cells affects circadian rhythms, with hypermetabolic states linked to weaker circadian oscillations in both mouse and human tumor cells.

This study examines metabolic changes in Drosophila short sleep mutants during the dark period, revealing altered metabolite levels and rhythmicity patterns compared to wild type.

This study shows that Dif, an NFκB transcription factor in Drosophila, regulates daily sleep and recovery sleep after sleep deprivation, with effects mediated through neuronal pathways.

This study shows the gut microbiome enhances metabolite cycling in Drosophila, interacting with the circadian clock and diet, with high-protein diets increasing cycling and high-sugar diets suppressing it.

This study shows mitochondrial dysfunction in the blood-brain barrier of 22qDS patients and mice, leading to impaired barrier function and social memory, which is corrected by mitochondrial treatment.

This study uses isotope tracing to show rhythmic glucose metabolism in Drosophila, revealing internal mechanisms controlling metabolic homeostasis across day and night.

The paper shows that sleepiness, not total sleep amount, increases seizure risk in Drosophila models by identifying the role of sleep-promoting circuits and serotonin receptors.

The paper identifies acylcarnitines as lipid species trafficked through the Drosophila BBB via sleep-dependent endocytosis, whose accumulation increases sleep need.

This study identifies polyamine elevation and nitrogen stress as toxic consequences of chronic sleep loss in Drosophila, linking them to metabolic dysfunction and reduced survival.

This study shows ecdysone acts through cortex glia to regulate sleep in Drosophila by modulating lipid metabolism.

The paper identifies multiple mechanisms by which Drosophila clock neurons transmit time-of-day signals to the pars intercerebralis to regulate circadian behaviors.

This study identifies AANAT1's role in astrocytes to regulate sleep homeostasis by modulating monoamine levels and rebound sleep after deprivation in Drosophila.

This study shows neonatal hyperoxia disrupts circadian protection from Influenza A in adulthood through lung intrinsic clock mechanisms, not viral burden.

This study identifies hugin+ neurons as a key interface between the sleep homeostat and circadian clock neurons, showing they regulate sleep timing and recovery.

The paper shows that the Drosophila blood-brain barrier has a circadian permeability rhythm driven by a clock in perineurial glia, with nighttime increased permeability enhancing drug efficacy.