RIPK3-dependent sequential recruitment of MLKL and RIPK1 drives PANoptotic cell death and chemokine production
Yu Yang, Yue Wang, Yang Wang, Erpeng Wu, Hao Chen, Liming Sun, Chi Zhang, Shuhui Cao, JINGWEN LI, Huiping Qiang, Lincheng Zhang, Yuqing Lou, Rong Qiao, Shenao Zhou, Yan Zhou, , Hua Zhong
This study identifies a RIPK3-dependent PANoptosome assembly mechanism that integrates pyroptotic, apoptotic, and necroptotic pathways, driving immunogenic cell death and chemokine production.
bioRxiv · Feb 26, 2025 · PreprintCell Biology