Hepatic stearoyl-CoA desaturase deficiency ameliorates hyperglycemia through bile acid signaling in an insulin-independent manner
Mugagga Kalyesubula, Daehan Kim, Woo Sung Kim, Nicole B. Wicker, Jonathan Williams, Veronica Pegkou Christofi, Ethan Anderson, Jacqueline R. Miller, Dylan Cootway, Kaela Groppel, Daniel Bergman, Snehal N. Chaudhari, James Mukasa Ntambi
This study shows that liver-specific SCD1 deficiency reduces hyperglycemia and hepatic steatosis in T1D through bile acid-FXR-Glut1 signaling, independent of insulin.
bioRxiv · Jul 8, 2026 · PreprintBiochemistry