Jonathan Williams

Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism

This study shows that folic acid polyglutamylation activates MAP2K5 signaling to promote adipocyte lipid breakdown, revealing a novel role for folate in lipid homeostasis.

Gut microbiome derived folate metabolite suppresses colorectal cancer progression

The paper shows that gut microbiota-derived folinic acid suppresses colorectal cancer progression by inhibiting calpain-2 and stabilizing E-cadherin.

Hepatic stearoyl-CoA desaturase deficiency ameliorates hyperglycemia through bile acid signaling in an insulin-independent manner

This study shows that liver-specific SCD1 deficiency reduces hyperglycemia and hepatic steatosis in T1D through bile acid-FXR-Glut1 signaling, independent of insulin.

Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation

The paper identifies a gut microbial metabolite of methotrexate that alleviates gut inflammation by promoting mitochondrial STAT3 signaling.

ADCY3 Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis

Thermodynamics shape the in vivo enzyme burden of glycolytic pathways

The paper quantifies enzyme burdens in glycolytic pathways of three bacteria, finding that thermodynamically favorable pathways require less enzymatic protein to sustain the same flux.