Author

Ethan Rosati

Huntsman Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alexander WangiD· 2 shared Djordje AtanackoviciD· 2 shared Jillian M. BakeriD· 2 shared Kenneth A. DietzeiD· 2 shared Tim LuetkensiD· 2 shared Wenxiang Sun· 2 shared Xiaoxuan FaniD· 2 shared Aaron P. RapoportiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Alexander WangORCID

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2 papers

Recent·Most cited

Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function

Kenneth A. Dietze, Kiet Nguyen, Aashli Pathni, F. Fazekas, Wenxiang Sun, Ethan Rosati, Jillian M. Baker, Maday Galeana Figueroa, Etse Gebru, Daniel Yamoah, Rediet Mulatu, Alexander Wang, Aaron P. Rapoport, David Henry Lum, Xiaoxuan Fan, , Tim Luetkens

This study shows that inhibiting cathepsin B prevents CAR T cell fratricide and exhaustion by blocking trogocytosis, improving CAR T cell persistence and anti-tumor activity.

Signal Transduction and Targeted Therapy · Apr 22, 2026Peer-reviewedBioengineering

Restricting CAR T Cell Trafficking Expands Targetable Antigen Space

Erin A. Morales, Kenneth A. Dietze, Jillian M. Baker, Alexander Wang, Stephanie V. Avila, Fiorella Iglesias, Sabarinath V. Radhakrishnan, Erica Vander Mause, Michael L. Olson, Wenxiang Sun, Ethan Rosati, Sadie L. Chidester, Thierry Iraguha, Xiaoxuan Fan, Djordje Atanackovic, Tim Luetkens

The paper shows that modifying integrin-mediated adhesion in CAR T cells prevents CNS targeting while maintaining anti-tumor activity against Ewing sarcoma.

bioRxiv · Feb 8, 2024 · PreprintBioengineering