Restricting CAR T Cell Trafficking Expands Targetable Antigen Space
Erin A. Morales, Kenneth A. Dietze, Jillian M. Baker, Alexander Wang, Stephanie V. Avila, Fiorella Iglesias, Sabarinath V. Radhakrishnan, Erica Vander Mause, Michael L. Olson, Wenxiang Sun, Ethan Rosati, Sadie L. Chidester, Thierry Iraguha, Xiaoxuan Fan, Djordje Atanackovic, Tim Luetkens
The paper shows that modifying integrin-mediated adhesion in CAR T cells prevents CNS targeting while maintaining anti-tumor activity against Ewing sarcoma.
bioRxiv · Feb 8, 2024 · PreprintBioengineering