Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system
R. L. Baerentsen, S. V. Nielsen, R. B. Skjerning, J. Lyngso, F. Bisiak, J. S. Pedersen, K. Gerdes, M. A. Sorensen, D. E. Brodersen
The paper investigates the structural basis of kinase inhibition in the E. coli HipBST toxin-antitoxin system, showing how HipS inhibits HipT through active site insertion and how phosphorylation affects complex flexibility.
bioRxiv · Jan 28, 2022 · PreprintMicrobiology