S. V. Nielsen

The paper identifies a novel ZW sex chromosome system on LG3 in Shinisaurus, with Foxl2 as a candidate primary sex determining gene.

The paper investigates the structural basis of kinase inhibition in the E. coli HipBST toxin-antitoxin system, showing how HipS inhibits HipT through active site insertion and how phosphorylation affects complex flexibility.

The paper identifies two PQC degrons in DHFR that become exposed in disease-linked missense variants, leading to proteasomal degradation.

The paper presents the first chromosome-level gecko genome and identifies multiple sex chromosome transitions in Sphaerodactylus geckos.

This study analyzes tooth loss across 200 million years of frog evolution, finding repeated losses in frogs linked to diet and jaw morphology but not body size.

The paper analyzes variant effects on protein activity and abundance in NUDT15 and PTEN, finding that a third of variants cause loss of function and half of these also reduce abundance.

The paper identifies structural destabilization and degradation of MLH1 variants in Lynch syndrome, linking reduced cellular levels to loss-of-function and suggesting stability predictions for diagnostic use.

The paper uses transcriptomic data to identify a nocturnal bottleneck in the ancestor of gecko lizards, suggesting evolutionary changes in photoreceptor cells and gene expression.