ImmunologybioRxiv
A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants
M. Diard, E. Bakkeren, D. Hoces…·E. Slack
This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.
DOI 10.1038/s41564-021-00911-1