A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants
M. Diard, E. Bakkeren, D. Hoces, V. Lentsch, M. Arnoldini, F. Boehi, K. Schumann-Moor, J. Adamcik, L. Piccoli, A. Lanzavecchia, B. Stadtmueller, N. Donohue, M. Vanderwoude, P. Viollier, L. Falquet, , E. Slack
This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.
bioRxiv · May 13, 2021Immunology