E. Slack

Salmonella-driven Intestinal Edema in Mice is Characterized by Tensed Fibronectin Fibers

This study identifies tensed fibronectin fibers in Salmonella-induced intestinal edema in mice, highlighting their potential role in maintaining tissue integrity during inflammation.

Quantifying the varying harvest of fermentation products from the human gut microbiota

The paper quantifies the metabolic flux of fermentation products from the gut microbiota, showing it varies with diet but not microbiota composition.

Surface crosslinking of virus-like particles increases resistance to proteases, low pH and mechanical stress for mucosal applications

This study enhances the stability of virus-like particles (VLPs) against environmental stressors by surface crosslinking, without affecting their vaccine function.

Nanoscale clustering by O-antigen-Secretory Immunoglobulin-A binding limits outer membrane diffusion by encaging individual Salmonella cells

The paper shows SIgA binding to Salmonella O-antigen nanoscale crosslinks the outer membrane, leading to biased inheritance and accelerated IgA escape through phase-variation.

Targeted induction of gut-microbial metabolism acutely affects feeding patterns and clock gene expression in the host

This study shows that increasing gut microbial metabolism in mice affects host clock gene expression and reduces food intake beyond microbial calorie contribution.

A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs

This study evaluates an inactivated Salmonella Typhimurium vaccine in pigs, showing strong and long-lasting immune responses with improved safety and seroconversion compared to live vaccines.

Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut

This study shows that microbiota colonization affects T cell activation thresholds in the gut, with immune system status and TCR specificity influencing responses to colonizing bacteria.

Vaccine-enhanced competition permits rational bacterial strain replacement in the gut

The paper demonstrates that oral vaccination combined with engineered competitor strains can exclude pathogens and replace bacterial strains in the mouse gut.

Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide is dependent on the resident microbiota

This study quantifies colonization bottlenecks and growth dynamics of Bacteroides thetaiotaomicron in the gut, showing that capsular polysaccharide provides a fitness advantage dependent on microbiota composition.

Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

A rationally designed oral vaccine induces Immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

This paper shows that an oral vaccine inducing IgA in mice can direct Salmonella to evolve into less virulent variants with shorter O-antigens.