Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8
L. M. Langer, F. Bonneau, Y. Gat, E. Conti
This study presents cryo-EM structures of SMG1-9 and SMG1-8-9 complexes bound to inhibitors or ATP analogs, revealing how SMG1 is autoinhibited by its insertion domain and stabilized by SMG8.
bioRxiv · Jul 28, 2021Biochemistry