Optogenetic confirmation of transverse-tubular membrane excitability in intact cardiac myocytes
M. Scardigli, M. Pasek, L. Santini, C. Palandri, E. Conti, C. Crocini, M. Campione, L. Loew, A. A. F. de Vries, D. Pijnappels, F. Pavone, C. Poggesi, E. Cerbai, R. Coppini, P. Kohl, , L. Sacconi
The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.
bioRxiv · Nov 29, 2023 · PreprintPhysiology