Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids
I. Schultz-Pernice, A. Fahmi, F. Britto, M. Liniger, Y.-C. Chiu, T. David, B. I. Oliveira Esteves, A. Golomingi, B. Zumkehr, M. Gerber, D. Jandrasits, R. Zuest, S. Steiner, C. Wotzkow, F. Blank, , M. P. Alves
This study shows MPXV spreads cell-to-cell in human neural organoids, causing neuronal death and neuritic bead formation, and identifies tecovirimat as effective in reducing viral load.
bioRxiv · Sep 19, 2023Microbiology