Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors
U. Lopez-Sanchez, L. J. Munro, L. K. Ladefoged, A. J. Pedersen, C. C. Brun, S. M. Lyngby, D. Baud, M. G. Pedersen, S. C. R. Lummis, B. Bang-Andersen, B. Schiott, C. Chipot, G. Schoehn, J. Neyton, F. Dehez, , A. S. Kristensen
This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.
bioRxiv · Feb 23, 2024 · PreprintBiochemistry