Author

F. Clarelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

P. Abel zur Wiesch· 2 shared T. Cohen· 2 shared A. C. Palmer· 1 shared A. Palmer· 1 shared B. Singh· 1 shared C. Hemez· 1 shared L. Chindelevitch· 1 shared M. Storflor· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

P. Abel zur Wiesch

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2 papers

Recent·Most cited

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

C. Hemez, F. Clarelli, A. C. Palmer, L. Chindelevitch, T. Cohen, P. Abel zur Wiesch

This study models how antibiotic mechanisms affect resistance mutation fitness, finding that drug type has little impact on resistance selection but that heterogeneous binding enables secondary mutations under certain conditions.

bioRxiv · Jun 1, 2020Pharmacology & Toxicology

Drug-target binding quantitatively predicts optimal antibiotic dose levels

F. Clarelli, A. Palmer, B. Singh, M. Storflor, S. Lauksund, T. Cohen, S. Abel, P. Abel zur Wiesch

This paper develops a computational model to predict antibiotic dose-response relationships from drug-target binding parameters and validates it with clinical isolates.

bioRxiv · Jun 27, 2019Biochemistry