Identification of serotonin as a gut regulator of liver hepcidin expression
T. Coman, M. Falabregue, J. Rossignol, P. Bonneau, M. Djebar, A. Bigorgne, J. R. Mathieu, M. Foretz, L. Kautz, K. Peoc'h, J.-M. Launay, L. Maroteaux, C. Peyssonnaux, O. Hermine, F. Cote
The paper identifies serotonin as a gut-derived regulator of liver hepcidin expression, showing it represses hepcidin through a 5-HT2B receptor-dependent pathway and is conserved in humans.
bioRxiv · Sep 16, 2021 · PreprintPhysiology