M. Foretz

Exercise training adaptations in liver glycogen and glycerolipids require hepatic AMP-activated protein kinase in mice

This study shows that AMPK is necessary for exercise-induced liver adaptations in glycogen and lipid metabolism in mice.

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death

This study shows that AMPK-1/2 deficiency in smooth muscles leads to persistent pulmonary hypertension and premature death in mice, with no systemic vasculopathy.

Metformin improves glycemia independently of skeletal muscle AMPK via enhanced intestinal glucose clearance

This study shows metformin reduces blood glucose through improved intestinal glucose clearance, not via skeletal muscle AMPK activation, challenging current understanding of its mechanism.

Identification of serotonin as a gut regulator of liver hepcidin expression

The paper identifies serotonin as a gut-derived regulator of liver hepcidin expression, showing it represses hepcidin through a 5-HT2B receptor-dependent pathway and is conserved in humans.

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

Myeloid deletion and therapeutic activation of AMP-activated protein kinase (AMPK) do not alter atherosclerosis in male or female mice

This study shows that deleting AMPK in myeloid cells or activating it therapeutically does not affect atherosclerosis in male or female mice.

The hypoxic ventilatory response is facilitated by the activation of Lkb1-AMPK signalling pathways downstream of the carotid bodies

This study shows that Lkb1-AMPK signaling, but not CaMKK2, is essential for the hypoxic ventilatory response downstream of the carotid bodies.