Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence and late clinical metastasis in a Beclin-1-dependent manner.
C. Nicco, M. Thomas, J. Guillermet-Guibert, M. Havard, F. Laurent-Tchenio, L. Doridot, F. Dautry, F. Batteux, T. Tchenio
This study shows that mTOR regulates self-sustained quiescence in cancer cells, which contributes to tumor indolence and late metastasis through Beclin-1 dependence.
bioRxiv · May 5, 2022Cancer Biology