M. Thomas

Dnmt3a-mediated de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells

This paper shows that Dnmt3a-mediated DNA methylation is essential for maintaining lineage commitment and function of memory Th1 and Tfh cells, and that early inhibition of this process can enhance Tfh cell differentiation.

Compound heterozygous DAW1 variants reveal tissue-specific roles in left-right patterning and congenital heart disease without primary ciliary dyskinesia

The paper identifies DAW1 variants in a patient with heterotaxy and congenital heart disease, showing tissue-specific functional effects without primary ciliary dyskinesia.

Millennial-scale societal shifts drive the widespread loss of a marine ecosystem

The paper reconstructs the historical distribution and loss of oyster reefs in China over 7600 years, linking their decline to millennial-scale overexploitation and societal shifts.

Multidrug resistance plasmids commonly reprogramme expression of metabolic genes in Escherichia coli

This study introduces eight MDR plasmids into E. coli and shows varying transcriptional impacts and fitness costs, with metabolic genes frequently affected.

Single-nucleus transcriptomics of epicardial adipose tissue from females reveals exercise control of innate and adaptive immune cells

This study uses snRNA-seq to analyze how exercise affects immune and mesenchymal cell interactions in epicardial adipose tissue of female pigs with coronary artery disease.

What makes a temperate phage an effective bacterial weapon?

This study identifies key traits determining the effectiveness of temperate phages as bacterial weapons and shows how their impact depends on host frequency and environmental factors.

Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

This study shows cancer-associated fibroblasts enhance drug resistance in ALK-driven lung adenocarcinoma by promoting lipid biosynthesis and suppressing lipid peroxidation through AKT signaling.

Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for oriented CSR

The paper shows that core enhancers of the IgH 3RR preorganize B cell nuclei to facilitate class switch recombination by controlling nuclear positioning and loop formation.

Surveillance of Vermont wildlife in 2021-2022 reveals no detected SARS-CoV-2 viral RNA

The study tested 739 Vermont wildlife samples for SARS-CoV-2 and found no viral RNA, contrasting with findings in other North American deer populations.

Colorectal cancer detection and treatment with engineered probiotics

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer

This paper identifies glycodelin as a sex-specific factor influencing immunotherapy resistance in NSCLC, showing it impairs survival in female patients and interacts with immune cells.

LDLR-mediated targeting and productive uptake of siRNA-peptide ligand conjugates in vitro and in vivo

The paper develops and evaluates siRNA-peptide conjugates targeting LDLR for siRNA delivery in vitro and in vivo.

Mutations in NAKED-ENDOSPERM IDD genes reveal functional interactions with SCARECROW and a maternal influence on leaf patterning in C4 grasses

The paper shows that mutations in NKD IDD genes worsen leaf patterning defects in C4 grasses but not C3 grasses, and identifies a maternal influence on leaf cell patterning during embryogenesis.

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

This study investigates SATB1's role in B-lineage cells, finding it is not essential for B cell development but acts as both a positive and negative regulator of Ig gene transcription in naive and activated B cells, respectively.

Interest of phenomic prediction as an alternative to genomic prediction in grapevine

This study applies phenomic prediction to grapevine using spectra to predict 15 traits, finding comparable predictive ability to genomic prediction across traits and populations.

The IgH Eμ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

The paper shows that IgH Eμ-MAR regions limit error-prone repair to the variable region of Ig genes by promoting UNG-dependent repair, affecting somatic hypermutation patterns.

A rapid alkalinization factor-like peptide EaF82 impairs tapetum degeneration during pollen development through induced ATP deficiency

The paper identifies EaF82, a RALF-like peptide, which delays tapetum degeneration in Arabidopsis by reducing ATP levels through AKIN10 interaction, impairing pollen development.

An end-to-end pipeline based on open source deep learning tools for reliable analysis of complex 3D images of Medaka ovaries

The paper develops an end-to-end pipeline using open-source deep learning tools to analyze complex 3D fluorescent images of Medaka ovaries for accurate quantitative measurement of ovarian content.

CIGB-300 peptide targets the CK2 phospho-acceptor domain on Human Papillomavirus E7 and disrupts the Retinoblastoma (RB) complex in cervical cancer cells

This study investigates how CIGB-300 peptide targets HPV-16 E7, disrupts CK2-mediated phosphorylation, and affects the E7-pRB interaction in cervical cancer cells.

YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro

This study shows YAP enhances cell-autonomous immune responses against intracellular Staphylococcus aureus by promoting autophagy and inflammation.

Mesenchymal Stromal Cells Donate Mitochondria to Articular Chondrocytes Exposed to Mitochondrial, Environmental, and Mechanical Stress

This paper shows that mesenchymal stromal cells transfer mitochondria to stressed chondrocytes in vitro and in situ, offering a new therapeutic strategy for osteoarthritis.

Mechanistic target of rapamycin (mTOR) regulates self-sustained quiescence, tumor indolence and late clinical metastasis in a Beclin-1-dependent manner.

This study shows that mTOR regulates self-sustained quiescence in cancer cells, which contributes to tumor indolence and late metastasis through Beclin-1 dependence.

Base editing screens map mutations affecting IFNγ signalling in cancer

This study uses base editing to identify mutations affecting IFNγ signalling in cancer, revealing loss- and gain-of-function variants with clinical relevance.

A practical guide for generating unsupervised, spectrogram-based latent space representations of animal vocalizations

This paper provides a guide for using spectrogram-based dimensionality reduction to create latent space representations of animal vocalizations, demonstrating its application on meerkat calls.

Imbalance between IL-36 receptor agonist and antagonist drives neutrophilic inflammation in COPD

The paper identifies an imbalance between IL-36 receptor agonist and antagonist in COPD patients, showing it drives neutrophilic inflammation and suggests a therapeutic antibody targeting IL-36R as a potential treatment.

Daily ranging and den usage patterns structure fission-fusion dynamics and social associations in spotted hyenas

This study examines how communal dens and daily movement patterns influence social interactions in spotted hyenas, revealing structured fission-fusion dynamics and social associations.

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

Single cell infection with influenza A virus using drop-based microfluidics

This study uses drop-based microfluidics to analyze influenza A virus infection at the single-cell level, showing stable drop environments and viral propagation.

A toxic friend: Genotoxic and mutagenic activity of the probiotic strain Escherichia coli Nissle 1917

This study shows that the probiotic Escherichia coli Nissle 1917 produces the genotoxin colibactin, which induces DNA damage and mutagenesis in vitro and in vivo.

CropMetaPop: a population genetics program to simulate the evolution of crop metapopulations

CropMetaPop simulates the genetic evolution of crop populations under human-mediated seed circulation and management strategies.