Design, synthesis and pharmacological characterization of the first photoswitchable small-molecule agonist for the Atypical Chemokine Receptor 3
S. Berenger, J. M. Adamska, F. Deflorian, C. de Graaf, C. B. Palmer, M. Szpakowska, A. Chevigne, I. J. P. de Esch, B. Zarzycka, H. F. Vischer, M. Wijtmans, R. Leurs
This paper designs and characterizes the first photoswitchable small-molecule agonist for ACKR3, showing its selectivity and light-controlled activation properties.
bioRxiv · Mar 20, 2024Pharmacology & Toxicology