R. Leurs

Design, synthesis and pharmacological characterization of the first photoswitchable small-molecule agonist for the Atypical Chemokine Receptor 3

This paper designs and characterizes the first photoswitchable small-molecule agonist for ACKR3, showing its selectivity and light-controlled activation properties.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

Pharmacological characterization of seven human histamine H3 receptor isoforms

This study pharmacologically characterizes seven human H3R isoforms, finding differences in agonist and inverse agonist binding affinities, with implications for drug discovery.

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

Pharmacological characterization and radiolabeling ofVUF15485, a high-affinity small-molecule agonist for theatypical chemokine receptor ACKR3

This paper characterizes VUF15485, a high-affinity ACKR3 agonist, and reports its radiolabeling and binding properties.

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling

This study investigates how adhesion triggers differentiation in Crithidia fasciculata, showing cAMP signaling is critical for attachment and involves reorganization of signaling components along the flagellum.