Author

C. de Graaf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Leurs· 3 shared A. Chevigne· 2 shared B. Zarzycka· 2 shared H. F. Vischer· 2 shared I. J. P. de Esch· 2 shared M. Arimont-Segura· 2 shared M. Szpakowska· 2 shared M. Wijtmans· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPharmacology & Toxicology

R. Leurs

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Design, synthesis and pharmacological characterization of the first photoswitchable small-molecule agonist for the Atypical Chemokine Receptor 3

S. Berenger, J. M. Adamska, F. Deflorian, C. de Graaf, C. B. Palmer, M. Szpakowska, A. Chevigne, I. J. P. de Esch, B. Zarzycka, H. F. Vischer, M. Wijtmans, R. Leurs

This paper designs and characterizes the first photoswitchable small-molecule agonist for ACKR3, showing its selectivity and light-controlled activation properties.

bioRxiv · Mar 20, 2024Pharmacology & Toxicology

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

O. Otun, C. Aljamous, E. Del Nero, M. Arimont-Segura, R. Bosma, B. Zarzycka, T. Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, X. Cong, C. BECHARA

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Pharmacological characterization and radiolabeling ofVUF15485, a high-affinity small-molecule agonist for theatypical chemokine receptor ACKR3

A. Zarca, I. Adlere, C. P. Viciano, M. Arimont-Segura, M. Meyrath, I. A. Simon, J. P. M. Bebelman, D. Laan, H. G. J. Custers, E. C. Janssen, K. L. Versteegh, R. Bosma, I. J. P. De Esch, H. F. Vischer, M. Wijtmans, , R. Leurs

This paper characterizes VUF15485, a high-affinity ACKR3 agonist, and reports its radiolabeling and binding properties.

bioRxiv · Jul 12, 2023Pharmacology & Toxicology

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

J. Hildebrand, M. Kauppi, I. Majewski, Z. Liu, A. Cox, S. Miyake, C. Hall, E. Petrie, M. Silk, M. Tanzer, S. Young, S. Garnish, J. Corbin, M. Stutz, P. Gangatirkar, , Venhoff

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

bioRxiv · May 15, 2019 · PreprintCell Biology