Cognate Antigen Engagement Induces HIV-1 Expression In CD4+ T Cells From People On Long-Term ART
M. Moskovjlevic, F. Dragoni, N. L. Board, F. Wu, J. Lai, H. Zhang, J. R. White, R. Ho, K. Lynn, P. Tebas, K. Mounzer, S. G. Deeks, L. J. Montaner, J. D. Siliciano, F. R. Simonetti, R. F. Siliciano
The paper shows that cognate antigen engagement in CD4+ T cells on long-term ART increases HIV-1 transcription through T cell activation, suggesting a role in viral rebound.
bioRxiv · Feb 27, 2024 · PreprintImmunology