H. Zhang

A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

Artificial light at night alters morphology, phenology, and reproductive capacity in an annual herb

This study shows that artificial light at night changes plant morphology, reproductive timing, and capacity in Elsholtzia densa, with mixed effects on fitness.

Repurposing the Memory-promoting Meclofenoxate Hydrochloride as a Treatment for Parkinson's Disease through Integrative Multi-omics analysis

This study identifies meclofenoxate hydrochloride as a potential treatment for Parkinson's disease by improving mitochondrial metabolism and brain function through multi-omics analysis and experimental validation.

Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for development and pathogenicity of Fusarium graminearum

This study identifies the GARP complex as a mediator that recruits retromer to the trans-Golgi network, facilitating the recycling of FgKex2 and FgSnc1, which is essential for growth, development, and pathogenicity of Fusarium graminearum.

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

Intraoperative Ablation Control Based on Real-time Necrosis Monitoring Feedback: Numerical Evaluation

This paper evaluates NFB control for ablation therapy, showing it provides more accurate control than TFB when NF model errors are present.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

BIG participates in the Arg/N-degron pathways and the hypoxia response in Arabidopsis thaliana.

This study identifies BIG as a component of N-degron pathways in Arabidopsis, showing it works with PRT6 to regulate hypoxia response and other processes.

The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice

This study identifies OsPrx20 as a key regulator of stress response and growth in rice, showing its dual role in osmotic stress tolerance and blast resistance.

Rating Pome Fruit Quality Traits Using Deep Learning and Image Processing

Granny uses deep learning and image processing to rate pome fruit quality traits, reducing rater bias and improving resolution while maintaining compatibility with existing standards.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Selective dissociation of vacant 70S ribosomes by RsfS promotes bacterial adaptation to nutrient starvation

This study shows RsfS selectively dissociates vacant 70S ribosomes during nutrient starvation, improving bacterial survival by conserving energy.

Bacterial-tyramine-induced renal-gut countercurrent flow regulates gut immune response by promoting ROS accumulation and gut peristalsis in the fly Bactrocera dorsalis

The paper identifies a renal-gut countercurrent flow in fruit flies that enhances gut immune response by promoting ROS accumulation and peristalsis through bacterial tyramine recognition.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Structural diversity and clustering of bacterial flagellar outer domains

The paper analyzes flagellar outer domains in bacterial species, revealing structural diversity and identifying new clusters of flagellin structures.

A change in cis-regulatory logic underlying obligate versus facultative muscle multinucleation in chordates

This study identifies cis-regulatory differences in the Mymk promoter that explain divergent muscle multinucleation patterns between vertebrates and tunicates.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

The paper develops a biosensor platform to measure GPCR activity in various contexts, revealing insights into coupling selectivity, pharmacogenomics, and signaling bias.

SUMO Promotes DNA Repair Protein Collaboration to Support Alterative Telomere Lengthening in the Absence of PML

This study shows SUMO promotes DNA repair protein collaboration for telomere maintenance in ALT cancer cells without PML bodies.

Cognate Antigen Engagement Induces HIV-1 Expression In CD4+ T Cells From People On Long-Term ART

The paper shows that cognate antigen engagement in CD4+ T cells on long-term ART increases HIV-1 transcription through T cell activation, suggesting a role in viral rebound.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Thermal acclimation of stem respiration reduces global carbon burden

The paper predicts and validates the temperature sensitivity of stem respiration, showing thermal acclimation reduces global carbon emissions.

Pooled CRISPR interference screening identifies crucial transcription factors in gas-fermenting Clostridium ljungdahlii

This study uses CRISPRi screening to identify transcription factors crucial for growth and carbon utilization in Clostridium ljungdahlii, improving ethanol production through deoR optimization.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

Loss of endogenous estrogen alters mitochondrial metabolism and muscle clock-related protein Rbm20 in female mdx mice

This study shows that estrogen loss in female mdx mice reduces exercise capacity and mitochondrial metabolism, but estrogen replacement therapy can reverse these effects and upregulate Rbm20.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.