Inhibition of integrin alpha V (CD51) reduces inflammation and transition to heart failure following pressure overload
C. Delacroix, A. Achab-Ali, P. Alayrac, M. Gandon-Renard, F. Drame, D. A. Sassoon, J.-S. Silvestre, J.-S. Hulot
This study shows that inhibiting integrin alpha V reduces inflammation and prevents heart failure progression in pressure-overloaded mice by modulating pro-inflammatory macrophages.
bioRxiv · Oct 10, 2022 · PreprintPharmacology & Toxicology